Endocrine Abstracts

Objectives: To investigate effects of testosterone in hypogonadal men with Crohn’s disease (CD).Design and methods: Thirteen men, aged 45–67 years were diagnosed with subnormal plasma testosterone. They received treatment with parenteral testosterone undecanoate. They also suffered from CD. The Crohn’s disease activity index (CDAI) (1) was used to assess the severity of the disease. Levels of testosterone and C-reactive protein (CRP) were ...

Objectives: Men with the metabolic syndrome (MetS) and type 2 diabetes (T2D) often have low testosterone levels. Elevating low testosterone levels may improve features of the MetS and glycemic control. In this analysis, we assessed effects of normalization of circulating testosterone on biomarkers of non-alcoholic fatty liver disease (NAFLD), and cardiovascular risk.Design and methods: In a single-blind, 52-week clinical trial, 32 hypogonadal men with th...

Background: For many years testosterone therapy in men was considered to be a risk factor for increasing the PSA level and prostate volume as well as blood count parameters. Objective was to investigate the influence of testosterone therapy on prostate and blood count in men with metabolic syndrome and hypogonadism.Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identifier: NCT00696748), 184 men suffering f...

Context: Low testosterone level in men is associated with the metabolic syndrome (MetS) as well as with depressive symptoms, low vitality and sexual dysfunction.Objective: To assess the effects of testosterone administration on these subjective symptoms, which have not extensively been studied in hypogonadal men with the MetS. Design: randomized, placebo-controlled trial. Setting: academic, ambulatory, referral centre. Patients: 184 men suffering from bo...

Background: Metabolic syndrome has a high prevalence in male population, leading to the high rate of cardiovascular disease and mortality. Numerous studies show that low androgen levels in men are associated with the metabolic syndrome. This study tested whether normalization of testosterone levels improves metabolic dysregulations and body composition.Methods: In a randomized, placebo-controlled, double-blind, phase III trial (ClinicalTrials.gov identif...

Background: Numerous studies (among which, studies of androgen deprivation in men with prostate cancer) show that low androgen levels in men are associated with the metabolic syndrome. Obesity and particularly visceral fat excess is associated with pro-thrombotic and pro-inflammatory states as well. This study tested whether normalization of testosterone levels improves markers of inflammation.Methods: In a randomized, placebo-controlled, double-blind, p...